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KMID : 0603820130190030245
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 3 p.245 ~ p.253
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Change Pattern of Species and Antimicrobial Susceptibility of Microorganisms Isolated from Blood Culture during 5 Years: 2008-2012
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Shin Kyung-Ah
Shin Kyeong-Seob
Hong Seung-Bok
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Abstract
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To provide reference data or guideline for empirical treatment of bloodstream infection, we studied a change pattern
in causative microorganisms and antimicrobial susceptibility in a general hospital at Gyeonggi province during five
years. We retrospectively reviewed the frequency of causative microorganisms and antimicrobial susceptibility results
of 5,782 microorganisms isolated from blood culture in a general hospital during the period from January 2008 to
December 2012. The most common pathogens were Escherichia coli (14.7%), Staphylococcus aureus (7.5%),
Streptococcus viridans group (4.9%), and Klebsiella pneumoniae (4.1%). The multiple microorganisms were isolated in
4.3% of bloodstream infection patients. The average contamination rate of blood culture during five years was 3.0%.
Methicillin-resistant S. aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and penicillin-resistant
Streptococcus pneumoniae were isolated at 62%, 27% and 11%, respectively. Cefotaxime-resistant E. coli and K.
pneumoniae was 20% and 18%, respectively. Imipenem-resistant Pseudomonas aeruginosa (IRPA) and Acinetobacter
baumannii (IRAB) was 25% and 66%, respectively. E. coli and S. aureus were most common pathogens isolated from
blood culture for five years. The increase of multidrug-resistant microorganisms, such as MRSA, VRE, ESBL, IRPA and
IRAB, requires more strict control of antibiotics and causes the need of the more updated guideline for the treatment of
blood stream infection.
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KEYWORD
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Blood culture, Frequency, Antimicrobial susceptibility
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